January 16, 2014 Hospira is issuing this Important Safety Information letter to remind Healthcare Providers to follow facility protocol and exercise caution when opening an ampul. Hospira has received reports of ampuls not properly breaking along the score lines. If an ampul is open without proper precaution and if the score line varies in depth, the break may not be clean and leave a sharp edge or shatter. A sharp edge may potentially pose a physical risk to the Health Care Provider as well as a delay in therapy. Always refer to specific facility policies and procedures for opening an ampul.